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Human Her3/ErbB3 Protein, Ultra Low Endotoxin (HER-HM103-UL) Summary
Product Description |
Recombinant Human Her3/ErbB3 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser20-Thr643. |
Product Background |
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets, ADC targets |
Human Her3/ErbB3 Protein, Ultra Low Endotoxin (HER-HM103-UL) Specifications/Details
Protein |
Her3/ErbB3 |
Synonyms |
ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; ERBB3 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser20-Thr643 |
Molecular Weight |
The protein has a predicted MW of 70.27 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human Her3, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag (Cat. NRG-HM201) with the EC50 of 17.1 ng/ml determined by ELISA. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human Her3, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag (Cat. NRG-HM201) with the EC50 of 17.1 ng/ml determined by ELISA. |
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Immobilized Human Her3, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HER3 Antibody, hFc Tag with the EC50 of 3.2 ng/ml determined by ELISA. |
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Human Her3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human Her3 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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