Name: Human HGF R/c-MET Protein (MET-HM101)
Brand: KactusBio
SKU: MET-HM101-100UG
Price: 215.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human HGF R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human HGF, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA.
Amino Acid Range: Glu25-Thr932

Catalog #MET-HM101

Size

100UG

500UG

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Human HGF R/c-MET Protein (MET-HM101) Summary

Product Description	Recombinant Human HGF R/c-MET Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu25-Thr932.
Product Background	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Human HGF R/c-MET Protein (MET-HM101) Specifications/Details

Protein	HGF R/c-MET
Synonyms	MET; oncogene MET; HGF R; HGF/SF receptor; AUTS9; cMET; Met (c-Met); RCCP2; SF receptor
Accession	P08581-1
Species	Human
Biotinylated	no
Amino Acid Range	Glu25-Thr932
Molecular Weight	The mature form of HGF R is a heterodimer which can be cleaved into α and β chain. The protein has a predicted MW of 32.5 kDa (α chain) and 72.1 kDa (β chain). Due to glycosylation, the protein migrates to 45-60 kDa (α subunit) and 80-100 kDa (β subunit) based on Bis-Tris PAGE result.
Activity	Immobilized Human HGF R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human HGF, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human HGF R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human HGF, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA.
	Immobilized Human HGF R, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HGF R Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA.
	Human HGF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human HGF R is greater than 95% as determined by SEC-HPLC.

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