• Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILNNFPHSI peptide
Catalog #MHC-HM493T
Price
Regular price $825.00
Regular price Sale price $825.00
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Size
Avantor VWR Fisher Scientific

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Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein (MHC-HM493T) Summary

Product Description

 Recombinant Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin.It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILNNFPHSI peptide.

Product Background

 Kita-Kyushu lung cancer antigen-1 (KK-LC-1), encoded by CT83, includes epitope peptides recognized by cytotoxic T lymphocytes (CTLs). CTLs against KK-LC-1 predominantly accumulate among tumor-infiltrating lymphocytes, which leads to a good response to adaptive immunotherapy. Except for the testis, KK-LC-1 is not expressed in normal tissues. It is expressed in 33%, 82%, and 75% of non-small cell lung cancers, GC, and triple-negative breast cancers, respectively.

Product Category

 Recombinant Protein / Antibody discovery / MHC / Peptide-MHCs

HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Specifications

Protein
 HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI)
Synonyms
 KK-LC-1; CT83; CXorf61; KKLC1;

MHC Form

 Tetramer

Allele

 HLA-A*02:01
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILNNFPHSI peptide
Molecular Weight
 The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reduced (N) condition based on Bis-Tris PAGE result.
Product Tag
 C-His-Avi

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%. Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%.
The purity of Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer is greater than 95% as determined by SEC-HPLC. The purity of Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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