Human HLA-A*02:01&B2M&TERT (ILAKFLHWL) Monomer Protein (MHC-HM473)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILAKFLHWL peptide

Catalog: MHC-HM473

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Product Description Recombinant Human HLA-A*02:01&B2M&TERT (ILAKFLHWL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and ILAKFLHWL peptide.

Product Background

The human telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) is expressed in many human cancer cells derived from multiple tissues, but infrequently in normal cells. Thus, hTERT is an attractive candidate target for tumor immunotherapy. hTERT:540–548 peptide (p540, ILAKFLHWL) has been identified as an effective HLA-A*0201-restricted T-cell epitope, an effective T-cell-based cancer treatment, including vaccines, against hTERT will likely require the identification of other MHC class I-restricted epitopes in this antigen.

Product Category

Recombinant Protein

Target

HLA-A*02:01&B2M&TERT (ILAKFLHWL) Monomer
Accession
MHC Form Monomer
Allele HLA-A*02:01

Species

Human

Amino Acid Range

Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILAKFLHWL peptide
Molecular Weight The protein has a predicted MW of 50.60 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human HLA-A*02:01&B2M&TERT (ILAKFLHWL) Monomer is greater than 95% as determined by SEC-HPLC.
Human HLA-A*02:01&B2M&TERT (ILAKFLHWL) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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