Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein (MHC-HM422T)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGAVGVGK peptide

Catalog: MHC-HM422T

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Product Description Recombinant Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin.It contains Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and VVGAVGVGK peptide.

Product Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Product Category

Recombinant Protein

Target

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer
MHC Form Tetramer
Allele HLA-A*11:01

Gene/Protein ID

AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVGAVGVGK

Species

Human

Exact Sequence

Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGAVGVGK peptide
Molecular Weight The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer is greater than 95% as determined by SEC-HPLC.
Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%.

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