• Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 5.82 nM as determined in SPR assay (Biacore T200).
  • Amino Acid Range: Pro113-Ala323(sIL-6R) & Val30-Met212(IL-6)
Catalog #HIL-HM106
Price
Regular price $450.00
Regular price Sale price $450.00
/
Size
Avantor VWR Fisher Scientific

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Human Hyper IL-6 Protein (HIL-HM106) Summary

Product Description

 Recombinant Human Hyper IL-6 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Pro113-Ala323 (sIL-6R) and Val30-Met212 (IL-6).

Product Background

 IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human Hyper IL-6 Protein (HIL-HM106) Specifications/Details

Protein
 IL-6
Synonyms
 IFN-beta-2; IL6; IL-6; BSF-2; CDF; MGI-2A; Interleukin-6; HSF; IFNB2; HGF;IFN-β-2
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Pro113-Ala323(sIL-6R) & Val30-Met212(IL-6)
Molecular Weight
 The protein has a predicted MW of 47.46 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 5.82 nM as determined in SPR assay (Biacore T200).
Product Tag
 C-His

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human Hyper IL-6, His Tag immobilized on CM5 Chip can bind Human gp130, His Tag (Cat. GP1-HM130) with an affinity constant of 5.82 nM as determined in SPR assay (Biacore T200). Human Hyper IL-6, His Tag immobilized on CM5 Chip can bind Human gp130, His Tag (Cat. GP1-HM130) with an affinity constant of 5.82 nM as determined in SPR assay (Biacore T200).
Human Hyper IL-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human Hyper IL-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Hyper IL-6 is greater than 95% as determined by SEC-HPLC. The purity of Human Hyper IL-6 is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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