Name: Human ICOS/CD278 (Q50A) Protein (ICO-HM20M)
Brand: KactusBio
SKU: ICO-HM20M-100UG
Price: 346.5 USD
Availability: InStock

Human ICOS/CD278 (Q50A) Protein (ICO-HM20M)

Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay (Biacore T200).

Human ICOS (Q50A) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human ICOS (Q50A) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 41.98 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Glu21-Phe141

Catalog #ICO-HM20M

Size

100UG

500UG

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Product Description	Recombinant Human ICOS/CD278 (Q50A) Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu21-Phe141.
Product Background	Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	ICOS/CD278 (Q50A)
Synonyms	AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850
Accession	Q9Y6W8-1
Species	Human
Biotinylated	no
Amino Acid Range	Glu21-Phe141
Molecular Weight	The protein has a predicted MW of 40.45 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 41.98 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay (Biacore T200).
	Human ICOS (Q50A) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human ICOS (Q50A) is greater than 95% as determined by SEC-HPLC.