Human IFN alpha/beta R2 Protein (IFN-HM10R)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 11.90 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Ile27-Lys243

Catalog: IFN-HM10R

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Product Description	Recombinant Human IFN alpha/beta R2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile27-Lys243.
Product Background	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.
Product Category	Recombinant Protein

Target	IFN alpha/beta R2
Synonyms	IFN-R-2; IFNAR2; IFNARB; IFNABR; IFN-alpha; beta receptor 2; beta receptor10; IFN-alpha/beta R2; IFN-alpha-REC; IFNbR2; IFN-R
Gene/Protein ID	P48551-2
Species	Human
Exact Sequence	Ile27-Lys243
Molecular Weight	The protein has a predicted MW of 25.8 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 11.90 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human IFN alpha/beta R2, His Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 11.90 nM as determined in SPR assay (Biacore T200).
	The purity of Human IFN alpha/beta R2 is greater than 95% as determined by SEC-HPLC.
	Human IFN alpha/beta R2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.