Name: Human IGF1R/CD221 Protein (IGF-HM11R)
Brand: KactusBio
SKU: IGF-HM11R-100UG
Price: 315.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag (Cat. IGF-HM201) with the EC50 of 0.90ug/ml determined by ELISA.
Amino Acid Range: Glu31-Asn932

Catalog #IGF-HM11R

Size

100UG

500UG

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Human IGF1R/CD221 Protein (IGF-HM11R) Summary

Product Description	Recombinant Human IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu31-Asn932.
Product Background	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human IGF1R/CD221 Protein (IGF-HM11R) Specifications/Details

Protein	IGF1R/CD221
Synonyms	CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216
Accession	P08069
Species	Human
Biotinylated	no
Amino Acid Range	Glu31-Asn932
Molecular Weight	The protein has a predicted MW of 80.4 kDa (alpha subunit) and 24.1 kDa (beta subunit). Due to the furin cleavage site and glycosylation, the protein migrates to 110-130 kDa and 45-55 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag (Cat. IGF-HM201) with the EC50 of 0.90ug/ml determined by ELISA.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag (Cat. IGF-HM201) with the EC50 of 0.90ug/ml determined by ELISA.
	Immobilized Human IGF1R, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IGF1R Antibody, hFc Tag with the EC50 of 4.3ng/ml determined by ELISA.
	Human IGF1R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IGF1R is greater than 90% as determined by SEC-HPLC.

Other Available Proteins:

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