Name: Human IGFBP-3R Protein (IGF-HM23R)
Brand: KactusBio
SKU: IGF-HM23R-100UG
Price: 330.0 USD
Availability: InStock

Catalog #IGF-HM23R

Size

100UG

500UG

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Product Description	Recombinant Human IGFBP-3R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser39-Arg204.
Product Background	Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.
Product Category	Recombinant Protein / Antibody discovery

Protein	IGFBP-3R
Synonyms	IGFBP-3R; GFBP3R; LOC124446; TMEM219
Accession	Q86XT9
Species	Human
Biotinylated	no
Amino Acid Range	Ser39-Arg204
Molecular Weight	The protein has a predicted MW of 44.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.