Human IGFBP-3R Protein (IGF-HM23R)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Ser39-Arg204
Catalog #IGF-HM23R
Regular price $330.00
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Product Description

Recombinant Human IGFBP-3R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser39-Arg204.

Product Background

Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

Product Category

Recombinant Protein / Antibody discovery

Protein

IGFBP-3R

Synonyms

IGFBP-3R; GFBP3R; LOC124446; TMEM219

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Ser39-Arg204

Molecular Weight

The protein has a predicted MW of 44.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IGFBP-3R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human IGFBP-3R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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support@kactusbio.us

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