Human IgG4 Fc Protein (IGG-HM004)

  • Express System: HEK293
  • Product Tag: No Tag
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 1.365 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Glu99-Gly326

Catalog: IGG-HM004

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Product Description Recombinant Human IgG4 Fc Protein is expressed from HEK293 without tag.It contains Glu99-Gly326.

Product Background

It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs.

Product Category

Recombinant Protein

Target

IgG4 Fc
Synonyms IGHG4
Accession

Species

Human

Amino Acid Range

Glu99-Gly326
Molecular Weight The protein has a predicted MW of 25.8 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 1.365 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

No Tag

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human IgG4 Fc, No Tag with an affinity constant of 1.365 uM as determined in SPR assay (Biacore T200).
The purity of Human IgG4 Fc is greater than 95% as determined by SEC-HPLC.
Human IgG4 Fc on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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