Human IL-1 alpha/IL-1A Protein (IL1-HM20A)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.28 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Phe113-Thr271
Catalog #IL1-HM20A
Regular price $297.00
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Product Description

Recombinant Human IL-1 alpha/IL-1A Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Phe113-Thr271.

Product Background

The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.

Product Category

Recombinant Protein / Antibody discovery

Protein

IL-1 alpha/IL-1A

Synonyms

Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Phe113-Thr271

Molecular Weight

The protein has a predicted MW of 43.99 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 0.28 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-1R1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human IL-1 alpha, hFc Tag with an affinity constant of 0.28 uM as determined in SPR assay (Biacore T200). Human IL-1R1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human IL-1 alpha, hFc Tag with an affinity constant of 0.28 uM as determined in SPR assay (Biacore T200).
Human IL-1 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human IL-1 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-1 alpha is greater than 95% as determined by SEC-HPLC. The purity of Human IL-1 alpha is greater than 95% as determined by SEC-HPLC.

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