Product Description |
Recombinant Human IL-1 Rrp2/IL-1 R6 (C154S, C262S) Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp20-Tyr337 (C154S,C262S). |
Product Background |
The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). IL1RL2 is a receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. |
Product Category |
Recombinant Protein |
Target |
IL-1 Rrp2/IL-1 R6 (C154S, C262S) |
Synonyms |
IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asp20-Tyr337(C154S, C262S) |
Molecular Weight |
The protein has a predicted MW of 37.2 kDa. Due to glycosylation, the protein migrates to 56-67 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human IL-1 Rrp2 (C154S, C262S), His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Human IL-1 Rrp2 (C154S, C262S), His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. |
|
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Human IL-1 Rrp2 (C154S, C262S) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-1 Rrp2 (C154S, C262S) is greater than 95% as determined by SEC-HPLC. |
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