Name: Human IL-1 Rrp2/IL-1 R6 Protein (IL1-HM2L2)
Brand: KactusBio
SKU: IL1-HM2L2-100UG
Price: 270.0 USD
Availability: InStock

Human IL-1 Rrp2/IL-1 R6 Protein (IL1-HM2L2)

Human IL-1 Rrp-2, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-1F10, His Tag with an affinity constant of 35.38 uM as determined in SPR assay (Biacore T200).

Immobilized Human IL-1 Rrp-2, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA (QC Test).

Human IL-1 Rrp2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human IL-1 Rrp2 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-1 Rrp-2, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA (QC Test). The affinity constant of 35.38 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Asp20-Arg335

Catalog #IL1-HM2L2

Size

100UG

500UG

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Product Description	Recombinant Human IL-1 Rrp2/IL-1 R6 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Asp20-Arg335.
Product Background	The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). IL1RL2 is a receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-1 Rrp2/IL-1 R6
Synonyms	IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R
Accession	Q9HB29-1
Species	Human
Biotinylated	no
Amino Acid Range	Asp20-Arg335
Molecular Weight	The protein has a predicted MW of 62.6 kDa. Due to glycosylation, the protein migrates to 75-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human IL-1 Rrp-2, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA (QC Test). The affinity constant of 35.38 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human IL-1 Rrp-2, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-1F10, His Tag with an affinity constant of 35.38 uM as determined in SPR assay (Biacore T200).
	Immobilized Human IL-1 Rrp-2, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-IL-1 Rrp-2 Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA (QC Test).
	Human IL-1 Rrp2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-1 Rrp2 is greater than 95% as determined by SEC-HPLC.