Human IL-13 Protein (IL1-HM213)
Catalog: IL1-HM213
Order now get it on
Product Description | Recombinant Human IL-13 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Gly21-Asn132. |
Product Background |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity). |
Product Category |
Recombinant Protein |
Target |
IL-13 |
Synonyms | IL13; IL-13; interleukin 13; NC30; P600; ALRH; BHR1; MGC116786; MGC116788; MGC116789 |
Gene/Protein ID |
AAK53823 |
Species |
Human |
Exact Sequence |
Gly21-Asn132 |
Molecular Weight | The protein has a predicted MW of 39.6 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Biotinylated Human IL-13Ra1, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human IL-13, hFc Tag with the EC50 of 15.8ng/ml determined by ELISA. The affinity constant of 0.399 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
N-hFc |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
You may also be interested in
View more associated products