Human IL-17C Protein (ILC-HM417)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
Activity: The affinity constant of 1.84 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: His19-Val197

Catalog: ILC-HM417

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Product Description	Recombinant Human IL-17C Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Val197.
Product Background	Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Product Category	Recombinant Protein

Target	IL-17C
Synonyms	CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884
Gene/Protein ID	Q9P0M4
Species	Human
Exact Sequence	His19-Val197
Molecular Weight	The protein has a predicted MW of 22.6 kDa. Due to glycosylation, the protein migrates to 25 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 1.84 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM MES, 150mM NaCl (PH 6.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 150mM NaCl (PH 6.0).
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-17C, His Tag-with an affinity constant of 1.84 uM as determined in SPR assay (Biacore T200).
	Human IL-17C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.