Human IL-1R1 Protein (IL1-HM0R1)
  • Express System: HEK293
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 11.37 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Leu18-Thr332
Catalog #IL1-HM0R1
Regular price $315.00
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Product Description
Recombinant Human IL-1R1 Protein is expressed from HEK293 without tag.It contains Leu18-Thr332.
Product Background
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, role in different stages of cancer development.IL-1R1 is the main receptor for both ligands and is expressed by various cell types, including innate and adaptive immune cell types, epithelial cells, endothelial cells, adipocytes, chondrocytes, fibroblasts, etc. IL-1 and IL-1R1 receptor interaction leads to a set of common signaling pathways, mainly the NF-kB and MAP kinase pathways, as a result of complex positive and negative regulations.
Product Category
Recombinant Protein
Target
IL-1R1
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Leu18-Thr332
Molecular Weight
The protein has a predicted MW of 36.17 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 11.37 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
No Tag
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human IL-1 Beta, His Tag captured on CM5 Chip via Anti-his antibody can bind Human IL-1R1, No Tag with an affinity constant of 11.37 nM as determined in SPR assay (Biacore T200).
Human IL-1R1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-1R1 is greater than 95% as determined by SEC-HPLC.

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