Human IL-1R2/IL-1 RII/CD121b Protein (IL1-HM1R2)
Catalog: IL1-HM1R2
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| Product Description | Recombinant Human IL-1R2/IL-1 RII/CD121b Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe14-Glu343. |
Product Background |
Interleukin (IL)-1 has been reported to be involved in the development of tuberculosis (TB). IL1R1 and IL1R2 encode a cytokine receptor that belongs to the IL-1 receptor family.IL1R2 (Interleukin 1 Receptor Type 2) is a Protein Coding gene. Diseases associated with IL1R2 include Endometriosis and Mastitis. Among its related pathways are Hematopoietic cell lineage and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, type II, blocking receptor activity. |
Product Category |
Recombinant Protein |
Target |
IL-1R2/IL-1 RII/CD121b |
| Synonyms | IL-1R-2; IL-1RT-2; IL-1RT2; CDw121b; IL-1R-beta; CD121b; IL1RB; IL1R2; IL-1 RII; MGC47725 |
Gene/Protein ID |
NP_004624.1 |
Species |
Human |
Exact Sequence |
Phe14-Glu343 |
| Molecular Weight | The protein has a predicted MW of 38.9 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human IL-1R2, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human IL-1 Beta, His Tag with the EC50 of 30.9ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Human IL-1R2, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human IL-1 Beta, His Tag with the EC50 of 30.9ng/ml determined by ELISA. |
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The purity of Human IL-1R2 is greater than 90% as determined by SEC-HPLC. |
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Human IL-1R2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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