Human IL-1RL1/ST2 Protein (ST2-HM1L1)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human IL-33, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Lys19-Phe328

Catalog: ST2-HM1L1

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Product Description Recombinant Human IL-1RL1/ST2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys19-Phe328.

Product Background

IL1RL1(also known as ST2)-is a member of the IL1-receptor family-and serves as the receptor for IL-33. The-ST2 protein-has two isoforms including sST2 and the membrane-bound ST2 receptor, referred to as ST2L. Preclinical studies have demonstrated that binding of IL-33 to ST2L elicits a cardioprotective effect. ST2/IL-33 signaling may play an important role in intestinal disease.

Product Category

Recombinant Protein

Target

IL-1RL1/ST2
Synonyms IL1RL1; DER4; ST2; T1; FIT-1; IL33R; ST2L; ST2V; IL-1 R4; IL1R4; Ly84; MGC32623
Accession

Species

Human

Amino Acid Range

Lys19-Phe328
Molecular Weight The protein has a predicted MW of 36 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human IL-33, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human IL-33, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA.
The purity of Human IL-1RL1 is greater than 95% as determined by SEC-HPLC.
Human IL-1RL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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