Product Description |
Recombinant Human IL-1RL1/ST2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys19-Phe328. |
Product Background |
IL1RL1(also known as ST2)-is a member of the IL1-receptor family-and serves as the receptor for IL-33. The-ST2 protein-has two isoforms including sST2 and the membrane-bound ST2 receptor, referred to as ST2L. Preclinical studies have demonstrated that binding of IL-33 to ST2L elicits a cardioprotective effect. ST2/IL-33 signaling may play an important role in intestinal disease. |
Product Category |
Recombinant Protein |
Target |
IL-1RL1/ST2 |
Synonyms |
IL1RL1; DER4; ST2; T1; FIT-1; IL33R; ST2L; ST2V; IL-1 R4; IL1R4; Ly84; MGC32623 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys19-Phe328 |
Molecular Weight |
The protein has a predicted MW of 36 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human IL-33, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human IL-33, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA. |
|
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Human IL-1RL1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-1RL1 is greater than 95% as determined by SEC-HPLC. |
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