Human IL-1RL1/ST2 Protein (ST2-HM2L1)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-33, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, hFc Tag with the EC50 of 9.9ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Lys19-Phe328

Catalog: ST2-HM2L1

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Product Description	Recombinant Human IL-1RL1/ST2 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Lys19-Phe328.
Product Background	IL1RL1(also known as ST2)-is a member of the IL1-receptor family-and serves as the receptor for IL-33. The-ST2 protein-has two isoforms including sST2 and the membrane-bound ST2 receptor, referred to as ST2L. Preclinical studies have demonstrated that binding of IL-33 to ST2L elicits a cardioprotective effect. ST2/IL-33 signaling may play an important role in intestinal disease.
Product Category	Recombinant Protein

Target	IL-1RL1/ST2
Gene/Protein ID	Q01638-2
Species	Human
Exact Sequence	Lys19-Phe328
Molecular Weight	The protein has a predicted MW of 61.75 kDa. Due to glycosylation, the protein migrates to 75-100 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human IL-33, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, hFc Tag with the EC50 of 9.9ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human IL-33, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-1RL1, hFc Tag with the EC50 of 9.9ng/ml determined by ELISA.
	The purity of Human IL-1RL1 is greater than 95% as determined by SEC-HPLC.
	Human IL-1RL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.