Human IL-21R Protein (ILR-HM121)
Human IL-21R Protein (ILR-HM121)
Human IL-21R Protein (ILR-HM121)
Human IL-21R Protein (ILR-HM121)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, His Tag with the EC50 of 34.2ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Cys20-Glu232
Catalog #ILR-HM121
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Product Description
 Recombinant Human IL-21R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys20-Glu232.
Product Background
 IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Product Category
 Recombinant Protein
Target
 IL-21R
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Cys20-Glu232
Molecular Weight
 The protein has a predicted MW of 25.65 kDa. Due to glycosylation, the protein migrates to 43-50 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, His Tag with the EC50 of 34.2ng/ml determined by ELISA. See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, His Tag with the EC50 of 34.2ng/ml determined by ELISA.
Human IL-21R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-21R is greater than 95% as determined by SEC-HPLC.
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