Name: Human IL-21R Protein (ILR-HM221)
Brand: KactusBio
SKU: ILR-HM221-100UG
Price: 345.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Cys20-Pro236

Catalog #ILR-HM221

Size

100UG

500UG

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Product Description	Recombinant Human IL-21R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys20-Pro236.
Product Background	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-21R
Synonyms	IL-21 receptor; IL-21R; CD360; NILR
Accession	NP_068570.1
Species	Human
Biotinylated	no
Amino Acid Range	Cys20-Pro236
Molecular Weight	The protein has a predicted MW of 51.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA.
	Human IL-21R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-21R is greater than 95% as determined by SEC-HPLC.