Name: Human IL-21R Protein (ILR-HM221)
Brand: KactusBio
SKU: ILR-HM221-100UG
Price: 379.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Cys20-Pro236

Catalog #ILR-HM221

Size

100UG

500UG

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Human IL-21R Protein (ILR-HM221) Summary

Product Description	Recombinant Human IL-21R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys20-Pro236.
Product Background	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human IL-21R Protein (ILR-HM221) Specifications/Details

Protein	IL-21R
Synonyms	IL-21 receptor; IL-21R; CD360; NILR
Accession	NP_068570.1
Species	Human
Biotinylated	no
Amino Acid Range	Cys20-Pro236
Molecular Weight	The protein has a predicted MW of 51.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human IL-21, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 42.3ng/ml determined by ELISA.
	Human IL-21R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-21R is greater than 95% as determined by SEC-HPLC.