Human IL-22 Protein (IL2-HM122)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human IL-22, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Exact Sequence: Ala34-Ile179

Catalog: IL2-HM122

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Product Description Recombinant Human IL-22 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ala34-Ile179.

Product Background

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.

Product Category

Recombinant Protein

Target

IL-22
Synonyms Interleukin-22; IL-22; Cytokine Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; ZCYTO18

Gene/Protein ID

Q9GZX6

Species

Human

Exact Sequence

Ala34-Ile179
Molecular Weight The protein has a predicted MW of 17.8 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human IL-22, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

N-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human IL-22, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA (QC Test).
Immobilized Human IL-22, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-22R alpha1&IL-10R beta, hFc Tag with the EC50 of 0.63ug/ml determined by ELISA.
The purity of Human IL-22 is greater than 95% as determined by SEC-HPLC.
Human IL-22 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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