Human IL-22R alpha 1 Protein (ILR-HM222)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
  • Activity: Immobilized Human IL-22, His Tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: His16-Thr228

Catalog: ILR-HM222

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Product Description Recombinant Human IL-22R alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.; It contains His16-Thr228.

Product Background

Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.

Product Category

Recombinant Protein

Target

IL-22R alpha 1
Synonyms IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11
Accession

Species

Human

Amino Acid Range

His16-Thr228
Molecular Weight The protein has a predicted MW of 51 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human IL-22, His Tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Less than 1 EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human IL-22, His Tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA (QC Test).
Immobilized Human IL-22R alpha 1, hFc Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC50 of 11.2 ng/ml determined by ELISA.
The purity of Human IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC.
Human IL-22R alpha 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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