Name: Human IL-23 alpha&IL-12 beta Protein, Ultra Low Endotoxin (IL2-HM1AB-UL)
Brand: KactusBio
SKU: IL2-HM1AB-UL-100UG
Price: 381.0 USD
Availability: InStock

Human IL-23 alpha&IL-12 beta Protein, Ultra Low Endotoxin (IL2-HM1AB-UL)

Immobilized Human IL-23R, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 46.4ng/ml determined by ELISA (QC Test).

Immobilized Human IL-23 alpha&IL-12 beta, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-IL-23 Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.

Human IL-23 alpha&IL-12 beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human IL-23 alpha&IL-12 beta is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-23R, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 46.4ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta)

Catalog #IL2-HM1AB-UL

Size

100UG

500UG

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Product Description	Recombinant Human IL-23 alpha&IL-12 beta Protein is expressed from HEK293 with His tag at the C-terminus of IL-23 alpha.It contains Arg20-Pro189 (IL-23 alpha) and Ile23-Ser328 (IL-12 beta).
Product Background	The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	IL-23 alpha&IL-12 beta
Synonyms	IL23 alpha; IL12 beta; IL23 alpha&IL12 beta ; IL12 β; IL23 alpha&IL12 β
Accession	Q9NPF7(IL-23 alpha)&P29460 (IL-12 beta)
Species	Human
Biotinylated	no
Amino Acid Range	Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta)
Molecular Weight	The protein has a predicted MW of 19.77 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 23 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result.
Activity	Immobilized Human IL-23R, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 46.4ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.01 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human IL-23R, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 46.4ng/ml determined by ELISA (QC Test).
	Immobilized Human IL-23 alpha&IL-12 beta, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-IL-23 Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.
	Human IL-23 alpha&IL-12 beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-23 alpha&IL-12 beta is greater than 95% as determined by SEC-HPLC.