Human IL-3 R Beta/CD131 Protein (IL3-HM1RB)
Human IL-3 R Beta/CD131 Protein (IL3-HM1RB)
Human IL-3 R Beta/CD131 Protein (IL3-HM1RB)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: The affinity constant of 4.13 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Thr17-Trp443
Catalog #IL3-HM1RB
Regular price $315.00
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Product Description

Recombinant Human IL-3 R Beta/CD131 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Thr17-Trp443.

Product Background

Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily.

Product Category

Recombinant Protein / Antibody discovery

Protein

IL-3 R Beta/CD131

Synonyms

CDw131; CD131; CSF2RB; IL3RB; IL5RB; AIC2A; Csfgmrb

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Thr17-Trp443

Molecular Weight

The protein has a predicted MW of 50.30 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 4.13 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Expression System

HEK293

Purity

>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-3 R Beta, His Tag immobilized on CM5 Chip can bind Human GM-CSF, No Tag with an affinity constant of 4.13 uM as determined in SPR assay (Biacore T200) (QC Test). Human IL-3 R Beta, His Tag immobilized on CM5 Chip can bind Human GM-CSF, No Tag with an affinity constant of 4.13 uM as determined in SPR assay (Biacore T200) (QC Test).
Human IL-3 R Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human IL-3 R Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-3 R Beta is greater than 95% as determined by SEC-HPLC. The purity of Human IL-3 R Beta is greater than 95% as determined by SEC-HPLC.

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