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Human IL-3 R Beta/CD131 Protein (IL3-HM1RB) Summary
Product Description |
Recombinant Human IL-3 R Beta/CD131 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Thr17-Trp443. |
Product Background |
Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human IL-3 R Beta/CD131 Protein (IL3-HM1RB) Specifications/Details
Protein |
IL-3 R Beta/CD131 |
Synonyms |
CDw131; CD131; CSF2RB; IL3RB; IL5RB; AIC2A; Csfgmrb |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Thr17-Trp443 |
Molecular Weight |
The protein has a predicted MW of 50.30 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 4.13 uM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Human IL-3 R Beta, His Tag immobilized on CM5 Chip can bind Human GM-CSF, No Tag with an affinity constant of 4.13 uM as determined in SPR assay (Biacore T200) (QC Test). |
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Human IL-3 R Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-3 R Beta is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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