• Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Arg5-Glu157
Catalog #ILB-HE036
Price
Regular price $37500
Regular price Sale price $37500
/
Size
Avantor VWR Fisher Scientific

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Human IL-36 Beta/IL-1F8 Protein (ILB-HE036) Summary

Product Description

 Recombinant Human IL-36 Beta/IL-1F8 Protein is expressed from E.coli without tag.It contains Arg5-Glu157.

Product Background

 Within the IL-1 superfamily, IL-36 plays a pivotal role in both innate and adaptive immune responses. Of the four IL-36 isoforms, three have agonist activity (IL-36α, IL-36β, IL-36γ) and the fourth has antagonist activity (IL-36 receptor antagonist [IL-36Ra]). All IL-36 isoforms bind to the IL-36 receptor (IL-36R). Binding of IL-36α/β/γ to the IL-36R recruits the IL-1 receptor accessory protein (IL-1RAcP) and activates downstream signalling pathways mediated by nuclear transcription factor kappa B and mitogen-activated protein kinase signalling pathways.

Human IL-36 Beta/IL-1F8 Protein (ILB-HE036) Specifications/Details

Protein
 IL-36 Beta/IL-1F8
Synonyms
 FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B; IL1F8; IL1H2;IL1 eta
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Arg5-Glu157
Molecular Weight
 The protein has a predicted MW of 17.23 kDa same as Bis-Tris PAGE result.
Product Tag
 No Tag
Fluorophore
 Unconjugated
Expression System
 E.coli
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose, 0.02% Tween-20 (pH 7.4).
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human IL-36 Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human IL-36 Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-36 Beta is greater than 95% as determined by SEC-HPLC. The purity of Human IL-36 Beta is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...