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Human IL-36 Beta/IL-1F8 Protein, Ultra Low Endotoxin (ILB-HE036-UL) Summary
Product Description |
Recombinant Human IL-36 Beta/IL-1F8 Protein is expressed from E.coli without tag.It contains Arg5-Glu157. |
Product Background |
Within the IL-1 superfamily, IL-36 plays a pivotal role in both innate and adaptive immune responses. Of the four IL-36 isoforms, three have agonist activity (IL-36α, IL-36β, IL-36γ) and the fourth has antagonist activity (IL-36 receptor antagonist [IL-36Ra]). All IL-36 isoforms bind to the IL-36 receptor (IL-36R). Binding of IL-36α/β/γ to the IL-36R recruits the IL-1 receptor accessory protein (IL-1RAcP) and activates downstream signalling pathways mediated by nuclear transcription factor kappa B and mitogen-activated protein kinase signalling pathways. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human IL-36 Beta/IL-1F8 Protein, Ultra Low Endotoxin (ILB-HE036-UL) Specifications/Details
Protein |
IL-36 Beta/IL-1F8 |
Synonyms |
FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B; IL1F8; IL1H2 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Arg5-Glu157 |
Molecular Weight |
The protein has a predicted MW of 17.23 kDa same as Bis-Tris PAGE result. |
Product Tag |
No Tag |
Fluorophore |
Unconjugated |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose, 0.02% Tween-20 (pH 7.4). |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human IL-36 Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human IL-36 Beta is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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