Product Description |
Recombinant Human IL-37 Protein is expressed from E.coli without tag.It contains Lys27-Asp192. |
Product Background |
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes. |
Product Category |
Recombinant Protein |
Target |
IL-37 |
Synonyms |
FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys27-Asp192 |
Molecular Weight |
The protein has a predicted MW of 18.55 kDa same as Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
No Tag |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in 20mM PBS, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-37, No Tag with an affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). |
|
|
Human IL-37 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human IL-37 is greater than 95% as determined by SEC-HPLC. |
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