- Express System: E.coli
- Product Tag: No Tag
- Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
- Activity: The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail.
- Amino Acid Range: Lys27-Asp192
Product Description |
Recombinant Human IL-37 Protein is expressed from E.coli without tag.It contains Lys27-Asp192. |
Product Background |
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes. |
Product Category |
Recombinant Protein |
Target |
IL-37 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys27-Asp192 |
Molecular Weight |
The protein has a predicted MW of 18.55 kDa same as Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
No Tag |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in 20mM PBS, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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