Name: Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447)
Brand: KactusBio
SKU: ITG-HM447-100UG
Price: 462.0 USD
Availability: InStock

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447)

Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test).

Immobilized Human ITGA4&ITGB7, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human MADCAM1, hFc Tag with the EC50 of 5.5ug/ml determined by ELISA.

Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

The purity of-Human ITGA4&ITGB7 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail

Catalog #ITG-HM447

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Tyr34-Thr977(ITGA4) acidic tail and Glu20-His723(ITGB7) basic tail.
Product Background	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer
Synonyms	Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7
Accession	P13612-1(ITGA4)&P26010-1(ITGB7)
Species	Human
Biotinylated	no
Amino Acid Range	Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Molecular Weight	The protein has a predicted MW of 112.5 kDa (ITGA4) & 81.3 kDa (ITGB7). Due to glycosylation,the protein migrates to 70 kDa, 80 kDa, 100-120 kDa and 130-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test).
	Immobilized Human ITGA4&ITGB7, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human MADCAM1, hFc Tag with the EC50 of 5.5ug/ml determined by ELISA.
	Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of-Human ITGA4&ITGB7 is greater than 95% as determined by SEC-HPLC.