Product Description |
Recombinant Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Tyr34-Thr977(ITGA4) acidic tail&Glu20-His723(ITGB7) basic tail. |
Product Background |
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha 4 beta 7 (ITGA4&ITGB7) |
Synonyms |
Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Tyr34-Thr977(ITGA4)acidic tail & Glu20-His723(ITGB7)basic tail |
Molecular Weight |
The protein has a predicted MW of 112.5 kDa (ITGA4) & 81.3 kDa (ITGB7). Due to glycosylation,the protein migrates to 70 kDa, 80 kDa, 100-120 kDa and 130-150 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). |
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|
Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. |
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The purity of-Human ITGA4&ITGB7 is greater than 95% as determined by SEC-HPLC. |
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