Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein (ITG-HM451)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human ITGA5&ITGB1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA5&ITGB1 Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Phe42-Tyr995(ITGA5) acidic tail & Gln21-Asp728(ITGB1) basic tail

Catalog: ITG-HM451

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Product Description Recombinant Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe42-Tyr995(ITGA5) acidic tail and Gln21-Asp728(ITGB1) basic tail.

Product Background

Integrin alpha 5/ beta 1, also known as VLA-5, is a widely expressed non-covalent heterodimer of a 160 kDa alpha 5 and a 130 kDa beta 1 Integrin subunit.Alpha 5/ beta 1 is up‑regulated on tumor vasculature and promotes angiogenesis.

Product Category

Recombinant Protein

Target

Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer
Synonyms Integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1

Gene/Protein ID

P08648(ITGA5)&P05556-1(ITGB1)

Species

Human

Exact Sequence

Phe42-Tyr995(ITGA5) acidic tail & Gln21-Asp728(ITGB1) basic tail
Molecular Weight The protein has a predicted MW of 111.8 kDa (ITGA5)&83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 100-140 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human ITGA5&ITGB1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA5&ITGB1 Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human ITGA5&ITGB1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA5&ITGB1 Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA.
The purity of Human ITGA5&ITGB1 is greater than 95% as determined by SEC-HPLC.
Human ITGA5&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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