Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM4V6)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail

Catalog: ITG-HM4V6

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Product Description Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail.

Product Background

ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

Product Category

Recombinant Protein

Target

Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Synonyms Integrin alpha V beta 6; ITGAV&ITGB6

Gene/Protein ID

P06756-1(ITGAV)&P18564-1(ITGB6)

Species

Human

Exact Sequence

Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
Molecular Weight The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3ng/ml determined by ELISA.
The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
Human ITGAV&ITGB6 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

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