Name: Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM4V6)
Brand: KactusBio
SKU: ITG-HM4V6-100UG
Price: 412.5 USD
Availability: InStock

Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM4V6)

Immobilized Human ITGAV&ITGB6, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3 ng/ml determined by ELISA (QC Test).

Immobilized Human ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB6 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA.

Human ITGAV&ITGB6 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Activity: Immobilized Human ITGAV&ITGB6, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3 ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail

Catalog #ITG-HM4V6

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail.
Product Background	ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Synonyms	αVβ6; Integrin alpha V beta 6; ITGAV&ITGB6;Integrin alpha V β 6
Accession	P06756-1(ITGAV)&P18564-1(ITGB6)
Species	Human
Biotinylated	no
Amino Acid Range	Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
Molecular Weight	The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGAV&ITGB6, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3 ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human ITGAV&ITGB6, His Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3 ng/ml determined by ELISA (QC Test).
	Immobilized Human ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB6 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA.
	Human ITGAV&ITGB6 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.