Product Description |
Recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus; It contains Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail. |
Product Background |
Integrin αVβ8 is a heterodimeric cell surface receptor involved in various cellular processes, including cell adhesion, migration, and signaling. It is recognized for its unique role in activating TGF-β and has been implicated in immune responses and tissue homeostasis. Due to its distinctive structure and function, integrin αVβ8 is considered atypical among integrin family members. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer |
Synonyms |
αVβ8; Integrin alpha V beta 8; TGAV&ITGB8;Integrin alpha V β 8 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail |
Molecular Weight |
The protein has a predicted MW of 114 kDa (ITGAV) and 76 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test). |
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Immobilized Human ITGAV&ITGB8, His Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA. |
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Human ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC. |
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