Name: Non-biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8)
Brand: KactusBio
SKU: ITG-HM4V8-100UG
Price: 412.5 USD
Availability: InStock

Non-biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8)

Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test).

Immobilized Human ITGAV&ITGB8, His Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.

Human ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Anti-alpha V Ab., hFc Tag on ProA-Biosensor can bind Biotinylated Human ITGAV&ITGB8, His-Avi Tag with an affinity constant of 0.61 µM as determined in BLI assay (Gator® Prime).

The purity of Human ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail

Catalog #ITG-HM4V8

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Non-biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8) Summary

Product Description	Recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGAV.It contains Phe31-Val992(ITGAV) acidic tail and Glu43-Arg684(ITGB8) basic tail.
Product Background	Integrin αVβ8 is a heterodimeric cell surface receptor involved in various cellular processes, including cell adhesion, migration, and signaling. It is recognized for its unique role in activating TGF-β and has been implicated in immune responses and tissue homeostasis. Due to its distinctive structure and function, integrin αVβ8 is considered atypical among integrin family members.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Non-biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8) Specifications/Details

Protein	Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer
Synonyms	αVβ8; Integrin alpha V beta 8; TGAV&ITGB8;Integrin alpha V β 8
Accession	P06756-1(ITGAV)&P26012-1(ITGB8)
Species	Human
Biotinylated	no
Amino Acid Range	Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail
Molecular Weight	The protein has a predicted MW of 114 kDa (ITGAV) and 76 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test).
	Immobilized Human ITGAV&ITGB8, His Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.
	Human ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-alpha V Ab., hFc Tag on ProA-Biosensor can bind Biotinylated Human ITGAV&ITGB8, His-Avi Tag with an affinity constant of 0.61 µM as determined in BLI assay (Gator® Prime).
	The purity of Human ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC.