Product Description |
Recombinant Human Integrin alpha X beta 2(ITGAX&ITGB2) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe20-Pro1107(ITGAX) acidic tail & Gln23-Asn700(ITGB2) basic tail. |
Product Background |
The integrin alpha X beta 2 (CD11c/CD18, p150,95) binds ligands through the I domain of the alpha X subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of alpha X beta 2 on dendritic cells and on other leukocytes, suggests a role in the immune response. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer |
Synonyms |
CD11C; SLEB6; CD18; ITGAX&ITGB2; ITGA; ITGB2 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Phe20-Pro1107(ITGAX) acidic tail & Gln23-Asn700(ITGB2) basic tail |
Molecular Weight |
The protein has a predicted MW of 125.50 kDa (ITGAX) and 79.50 kDa (ITGB2). Due to glycosylation, the protein migrates to 130-135 kDa (ITGAX) and 85-95 kDa (ITGB2) based on Bis-Tris PAGE result. |
Activity |
Immobilized Human ITGAX&ITGB2, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB2 Antibody, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Human ITGAX&ITGB2, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB2 Antibody, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test). |
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Human ITGAX&ITGB2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human ITGAX&ITGB2 is greater than 95% as determined by SEC-HPLC. |
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