Name: Human Kallikrein 5/KLK5 Protein (KLK-HM105)
Brand: KactusBio
SKU: KLK-HM105-100UG
Price: 300.0 USD
Availability: InStock

Human Kallikrein 5/KLK5 Protein (KLK-HM105)

Immobilized Human Kallikrein 5, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Kallikrein 5 Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA (QC Test).

Human Kallikrein 5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human Kallikrein 5 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Kallikrein 5, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Kallikrein 5 Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Val23-Ser293

Catalog #KLK-HM105

Size

100UG

500UG

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Product Description	Recombinant Human Kallikrein 5/KLK5 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val23-Ser293.
Product Background	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
Product Category	Recombinant Protein / Antibody discovery

Protein	Kallikrein 5/KLK5
Synonyms	Kallikrein c; Klnc; KLK5; KLKL2; KLK-L2; SCTE
Accession	Q9Y337
Species	Human
Biotinylated	no
Amino Acid Range	Val23-Ser293
Molecular Weight	The protein has a predicted MW of 30.7 kDa. Due to glycosylation, the protein migrates to 42-48 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human Kallikrein 5, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Kallikrein 5 Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM MES, 150mM NaCl (pH 5.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 150mM NaCl (pH 5.5).
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human Kallikrein 5, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Kallikrein 5 Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA (QC Test).
	Human Kallikrein 5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Kallikrein 5 is greater than 95% as determined by SEC-HPLC.