Name: Human Kallikrein 7/KLK7 Protein (pro form) (KLK-HM617)
Brand: KactusBio
SKU: KLK-HM617-100UG
Price: 412.5 USD
Availability: InStock

Human Kallikrein 7/KLK7 Protein (pro form) (KLK-HM617)

Immobilized Human Kallikrein 7, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kallikrein 7 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.

Human Kallikrein 7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human Kallikrein 7 is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Flag
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human Kallikrein 7, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kallikrein 7 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. See testing image for detail.Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >150 pmol/min/µg.
Amino Acid Range: Glu23-Arg253

Catalog #KLK-HM617

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Human Kallikrein 7/KLK7 Protein (pro form) (KLK-HM617) Summary

Product Description	Recombinant Human Kallikrein 7/KLK7 Protein (pro form) is expressed from HEK293 with His tag and Flag tag at the C-terminus. The protein needs to be activated by Thermolysin for an activated form.It contains Glu23-Arg253.
Product Background	Kallikrein 7 (KLK7) is a secreted serine protease with chymotrypsic protease activity. Abnormally high expression of KLK7 is closely related to the occurrence and development of various types of cancer. Therefore, KLK7 has been identified as a potential target for cancer drug development design in recent years. KLK7 mediates various biological and pathological processes in tumorigenesis, including cell proliferation, migration, invasion, angiogenesis, and cell metabolism, by hydrolyzing a series of substrates such as membrane proteins, extracellular matrix proteins, and cytokines.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human Kallikrein 7/KLK7 Protein (pro form) (KLK-HM617) Specifications/Details

Protein	Kallikrein 7/KLK7
Synonyms	Kallikrein-7; hK7; Serine protease 6; hSCCE; KLK7; PRSS6; SCCE
Accession	P49862
Species	Human
Biotinylated	no
Amino Acid Range	Glu23-Arg253
Molecular Weight	The protein has a predicted MW of 27.29 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human Kallikrein 7, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kallikrein 7 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. See testing image for detail.Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >150 pmol/min/µg.
Product Tag	C-His-Flag
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in 20mM HEPES, 150mM NaCl (pH 7.5).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human Kallikrein 7, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kallikrein 7 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.
	Human Kallikrein 7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Kallikrein 7 is greater than 90% as determined by SEC-HPLC.