Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein (MHC-HM440)
Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein (MHC-HM440)
Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein (MHC-HM440)
Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein (MHC-HM440)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M)and VVVGARGVGK peptide
Catalog #MHC-HM440
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Product Description
 Recombinant Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGARGVGK peptide.
Product Background
 Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Product Category
 Recombinant Protein
Target
 HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer
Synonyms
 MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
MHC Form
 Monomer
Allele
 HLA-A*11:01
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M)and VVVGARGVGK peptide
Molecular Weight
 The protein has a predicted MW of 50.30 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His-Avi
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer is greater than 95% as determined by SEC-HPLC.

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