Human Kremen-1 Protein (KRE-HM201)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Arg21-Thr392

Catalog: KRE-HM201

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Product Description Recombinant Human Kremen-1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg21-Thr392.

Product Background

 KREMEN1 (KRM1) has been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD), which poses a great threat to infants globally. KRM1 selectively binds to the mature viral particle above the canyon of the viral protein 1 (VP1) subunit and contacts across two adjacent asymmetry units. The key residues for receptor binding are conserved among most KRM1-dependent enteroviruses, suggesting a uniform mechanism for receptor binding.

Product Category

 Recombinant Protein

Target

 Kremen-1
Synonyms Kremen protein 1; KREMEN; KRM1; KREMEN1

Gene/Protein ID

 Q96MU8-1

Species

 Human

Exact Sequence

 Arg21-Thr392
Molecular Weight The protein has a predicted MW of 67.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human Kremen-1 is greater than 95% as determined by SEC-HPLC.
Human Kremen-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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