Human Kremen-2 Protein (KRE-HM102)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Kremen-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gly26-Ala364

Catalog: KRE-HM102

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Product Description Recombinant Human Kremen-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly26-Ala364.

Product Background

Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy.

Product Category

Recombinant Protein

Target

Kremen-2
Synonyms KRM2; KREMEN2; Kremen-2; Dickkopf receptor 2

Gene/Protein ID

Q8NCW0-1

Species

Human

Exact Sequence

Gly26-Ala364
Molecular Weight The protein has a predicted MW of 37.1 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Kremen-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Kremen-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA.
The purity of Human Kremen-2 is greater than 95% as determined by SEC-HPLC.
Human Kremen-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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