Product Description |
Recombinant Human L1CAM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile20-Glu1120. |
Product Background |
L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis. This is most likely due to the motility and invasion promoting function of L1CAM. L1CAM is a valuable diagnostic/prognostic marker and an attractive target for the therapy of several human cancers. |
Product Category |
Recombinant Protein |
Protein |
L1CAM |
Synonyms |
N-CAM-L1; NCAM-L1; CD171; L1CAM; CAML1; MIC5; CALL; CHL1; CHL-1; FLJ44930; L1CAM-2; MGC132578; HSAS; HSAS1; MASA; S10; SPG1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ile20-Glu1120 |
Molecular Weight |
The protein has a predicted MW of 124.6 kDa. Due to glycosylation, the protein migrates to 150-180 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human L1CAM, His Tag at 0.2ug/ml (100ul/well) on the plate. Dose response curve for Anti-L1CAM Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human L1CAM, His Tag at 0.2ug/ml (100ul/well) on the plate. Dose response curve for Anti-L1CAM Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA. |
|
|
Human L1CAM on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human L1CAM is greater than 95% as determined by SEC-HPLC. |
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