Name: Human LAG3/CD223 Protein (LAG-HM231)
Brand: KactusBio
SKU: LAG-HM231-100UG
Price: 297.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human FGL1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human LAG3, hFc Tag with the EC50 of 75.1ng/ml determined by ELISA.
Amino Acid Range: Leu23-Leu450

Catalog #LAG-HM231

Size

100UG

500UG

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Human LAG3/CD223 Protein (LAG-HM231) Summary

Product Description	Recombinant Human LAG3/CD223 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu23-Leu450.
Product Background	LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Human LAG3/CD223 Protein (LAG-HM231) Specifications/Details

Protein	LAG3/CD223
Synonyms	CD223; FDC; LAG3; LAG-3; sLAG-3
Accession	P18627-1
Species	Human
Biotinylated	no
Amino Acid Range	Leu23-Leu450
Molecular Weight	The protein has a predicted MW of 72.4 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human FGL1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human LAG3, hFc Tag with the EC50 of 75.1ng/ml determined by ELISA.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human FGL1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human LAG3, hFc Tag with the EC50 of 75.1ng/ml determined by ELISA.
	Human LAG3 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%
	The purity of Human LAG3 is greater than 90% as determined by SEC-HPLC.

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