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Human LAIR1/CD305 Protein, Ultra Low Endotoxin (LAI-HM2R1-UL) Summary
Product Description |
Recombinant Human LAIR1/CD305 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln22-His163. |
Product Background |
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human LAIR1/CD305 Protein, Ultra Low Endotoxin (LAI-HM2R1-UL) Specifications/Details
Protein |
LAIR1/CD305 |
Synonyms |
CD305; HLAIR1; LAIR1; LAIR-1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln22-His163 |
Molecular Weight |
The protein has a predicted MW of 42.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human LAIR1, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LAIR1 Antibody, hFc Tag with the EC50 of 42.6ng/ml determined by ELISA (QC Test). |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human LAIR1, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LAIR1 Antibody, hFc Tag with the EC50 of 42.6ng/ml determined by ELISA (QC Test). |
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Immobilized Human Collagen I, No Tag at 2ug/ml (50ul/well) on the plate. Dose response curve for Human LAIR1, hFc Tag with the EC50 of 1.17ug/ml determined by ELISA. |
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Human LAIR1 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. |
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The purity of Human LAIR1 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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