Human Latent GDF-8 Protein (GDF-HM108)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Asn24-Ser375

Catalog: GDF-HM108


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Product Description Recombinant Human Latent GDF-8 Protein is expressed from HEK293 with His tag at the N-terminus.It contains Asn24-Ser375.

Product Background

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-β family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a furin-like protease to yield an N-terminal prodomain and a C-terminal mature, signaling domain.

Product Category

Recombinant Protein


Latent GDF-8



Amino Acid Range

Molecular Weight The protein has a predicted MW of 41.19 kDa. Due to glycosylation, the protein migrates to 35-40 kDa and 45-55 kDa based on Tris-Bis PAGE result.

Product Tag


Express System

Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human Latent GDF-8 is greater than 95% as determined by SEC-HPLC.
Human Latent GDF-8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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