Product Description |
Recombinant Human Latexin-Protein is expressed from E.coli with His tag at the N-Terminus.It contains Glu2-Glu222. |
Product Background |
Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells. |
Product Category |
Recombinant Protein |
Target |
Latexin |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Glu2-Glu222 |
Molecular Weight |
The protein has a predicted MW of 27.16 kDa. The protein migrates to 30-35 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-His |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human Latexin-on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
Measured by its ability to inhibit carboxypeptidase A1 cleavage of the colorimetric peptide substrate Ac-Phe-Thiaphe-OH in the presence of 5,5'Dithio-bis (2-nitrobenzoic acid) (DTNB). The IC50-value is < 1 nM. |
|
|
The purity of Human Latexin is greater than 95% as determined by SEC-HPLC. |
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