Name: Human LRP-6 Protein (LRP-HM316)
Brand: KactusBio
SKU: LRP-HM316-100UG
Price: 264.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-mFc
Purity: > 90% as determined by Bis-Tris PAGE
Activity: Immobilized Human DKK1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 1.03ug/ml determined by ELISA (QC Test).
Amino Acid Range: Ala20-Pro630

Catalog #LRP-HM316

Size

100UG

500UG

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Human LRP-6 Protein (LRP-HM316) Summary

Product Description	Recombinant Human LRP-6 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Ala20-Pro630.
Product Background	Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human LRP-6 Protein (LRP-HM316) Specifications/Details

Protein	LRP-6
Synonyms	LRP-6; DCAD2; FLJ90062; FLJ90421;LRP6
Accession	O75581-1
Species	Human
Biotinylated	no
Amino Acid Range	Ala20-Pro630
Molecular Weight	The protein has a predicted MW of 95.32 kDa. Due to glycosylation, the protein migrates to 97-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human DKK1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 1.03ug/ml determined by ELISA (QC Test).
Product Tag	C-mFc
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human DKK1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 1.03ug/ml determined by ELISA (QC Test).
	Immobilized Human SOST, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 18.6ng/ml determined by ELISA.
	Immobilized Human LRP-6, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4ug/ml determined by ELISA.
	Human LRP-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	Loaded Human R spondin 1, His Tag on Anti-His-Biosensor can bind Human LRP-6, mFc Tag with an affinity constant of 8.97 nM as determined in BLI assay.

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