Product Description |
Recombinant Human LRP-6 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Ala20-Pro630. |
Product Background |
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. |
Product Category |
Recombinant Protein |
Target |
LRP-6 |
Synonyms |
LRP-6; DCAD2; FLJ90062; FLJ90421;LRP6 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala20-Pro630 |
Molecular Weight |
The protein has a predicted MW of 95.32 kDa. Due to glycosylation, the protein migrates to 97-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human SOST, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-mFc |
Express System |
HEK293 |
Purity |
>90% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human SOST, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1ng/ml determined by ELISA. |
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Immobilized Human DKK1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 0.58ug/ml determined by ELISA (QC Test). |
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Immobilized Human LRP-6, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4ug/ml determined by ELISA. |
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Human LRP-6 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. |
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