Name: Human LTBR Protein (LTB-HM201)
Brand: KactusBio
SKU: LTB-HM201-100UG
Price: 150.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc
Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Activity: Immobilized Human LIGHT, His Tag at 1 ug/ml (100 ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8 ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Gln31-Met227

Catalog #LTB-HM201

Size

100UG

500UG

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Product Description	Recombinant Human LTBR Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln31-Met227.
Product Background	Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB. TRAF3 functions as a negative regulator of LTBR signaling via both canonical and non-canonical NFkappaB pathways by two distinct mechanisms. These effects of TRAF3 depletion did not require LTBR signaling and were consistent with autonomous activation of the non-canonical NFkappaB pathway.
Product Category	Recombinant Protein / Antibody discovery

Protein	LTBR
Synonyms	TNFCR; TNFR3; TNFRSF3; LTBR; CD18; TNFR2-RP; TNFR-RP; LT-BETA-R; TNF-R-III; D12S370; LT-β-R
Accession	P36941-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln31-Met227
Molecular Weight	The protein has a predicted MW of 48.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human LIGHT, His Tag at 1 ug/ml (100 ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8 ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human LIGHT, His Tag at 1 ug/ml (100 ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8 ng/ml determined by ELISA (QC Test).
	Immobilized Human LTBR, hFc Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Biotinylated Anti-LTBR Antibody, hFc Tag with the EC50 20.7 ng/ml determined by ELISA.
	Human LTBR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human LTBR is greater than 95% as determined by SEC-HPLC.