Human LTBR Protein (LTB-HM201)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human LIGHT, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Gln31-Met227

Catalog: LTB-HM201

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Product Description	Recombinant Human LTBR Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln31-Met227.
Product Background	Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB.TRAF3 functions as a negative regulator of LTBR signaling via both canonical and non-canonical NFkappaB pathways by two distinct mechanisms. These effects of TRAF3 depletion did not require LTBR signaling and were consistent with autonomous activation of the non-canonical NFkappaB pathway.
Product Category	Recombinant Protein

Target	LTBR
Synonyms	TNFCR; TNFR3; TNFRSF3; LTBR; CD18; TNFR2-RP; TNFR-RP; LT-BETA-R; TNF-R-III; D12S370
Accession	P36941-1
Species	Human
Amino Acid Range	Gln31-Met227
Molecular Weight	The protein has a predicted MW of 48.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human LIGHT, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human LIGHT, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8ng/ml determined by ELISA (QC Test).
	Immobilized Human LTBR, hFc Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-LTBR Antibody, hFc Tag with the EC50 20.7ng/ml determined by ELISA.
	The purity of Human LTBR is greater than 95% as determined by SEC-HPLC.
	Human LTBR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.