Product Description |
Recombinant Human LY6G6D Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Asn20-Ser104. |
Product Background |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. |
Product Category |
Recombinant Protein |
Target |
LY6G6D |
Synonyms |
Protein Ly6-D; C6orf23; G6D; MEGT1; NG25 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asn20-Ser104 |
Molecular Weight |
The protein has a predicted MW of 35.87 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human LY6G6D, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LY6G6D Antibody, hFc Tag with the EC50 of 13.6ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human LY6G6D, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LY6G6D Antibody, hFc Tag with the EC50 of 13.6ng/ml determined by ELISA (QC Test). |
|
|
Human LY6G6D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human LY6G6D is greater than 95% as determined by SEC-HPLC. |
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