Product Description |
Recombinant Human MERTK/Mer Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala21-Ile505. |
Product Background |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. |
Product Category |
Recombinant Protein |
Target |
MERTK/Mer |
Synonyms |
MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala21-Ile505 |
Molecular Weight |
The protein has a predicted MW of 78.9 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human MERTK, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 3.34ug/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-mFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human MERTK, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 3.34ug/ml determined by ELISA (QC Test). |
|
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Human MERTK on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human MERTK is greater than 95% as determined by SEC-HPLC. |
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