Human MERTK/Mer Protein (MEK-HM301)
Catalog: MEK-HM301
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| Product Description | Recombinant Human MERTK/Mer Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala21-Ile505. |
Product Background |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. |
Product Category |
Recombinant Protein |
Target |
MERTK/Mer |
| Synonyms | MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12 |
Gene/Protein ID |
Q12866-1 |
Species |
Human |
Exact Sequence |
Ala21-Ile505 |
| Molecular Weight | The protein has a predicted MW of 78.9 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-mFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Human MERTK is greater than 95% as determined by SEC-HPLC. |
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Human MERTK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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