Human MERTK/Mer Protein (MEK-HM301)
Human MERTK/Mer Protein (MEK-HM301)
Human MERTK/Mer Protein (MEK-HM301)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human MERTK, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 3.34ug/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ala21-Ile505
Catalog #MEK-HM301
Regular price $270.00
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Product Description
Recombinant Human MERTK/Mer Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala21-Ile505.
Product Background
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.
Product Category
Recombinant Protein
Target
MERTK/Mer
Synonyms
MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ala21-Ile505
Molecular Weight
The protein has a predicted MW of 78.9 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human MERTK, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 3.34ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
C-mFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human MERTK, mFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 3.34ug/ml determined by ELISA (QC Test).
Human MERTK on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human MERTK is greater than 95% as determined by SEC-HPLC.

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