Product Description |
Recombinant Human/Mouse BMPR2 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser27-Thr150. |
Product Background |
Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembrane, kinase, and C-terminal cytoplasmic domains. Bone morphogenetic proteins (BMPs) engage the tetrameric complex, composed of BMPR2 and its corresponding type 1 receptors, which initiates SMAD proteins-mediated signal transduction leading to the expression of target genes implicated in the development or differentiation of the embryo, organs and bones. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
BMPR2 |
Synonyms |
BMPR-2; BMPR-II; PPH1 |
Accession |
|
Species |
Human/Mouse |
Biotinylated |
no |
Amino Acid Range |
Ser27-Thr150 |
Molecular Weight |
The protein has a predicted MW of 39.84 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.； -80°C for 3 months after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human/Mouse BMPR2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human/Mouse BMPR2 is greater than 95% as determined by SEC-HPLC. |
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