Human Mucin-1/MUC-1 Isoform Y Protein (MUC-HM2Y1)

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Amino Acid Range: Ser24-Gly158

Catalog #MUC-HM2Y1

Price

$412⁵⁰

Size

Order by 4pm ET for delivery on:

Human Mucin-1/MUC-1 Isoform Y Protein (MUC-HM2Y1) Summary

Product Description

Recombinant Human Mucin-1 Isoform Y Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ser24-Gly158.

Product Background

MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.

Human Mucin-1/MUC-1 Isoform Y Protein (MUC-HM2Y1) Specifications/Details

Protein	Mucin-1/MUC-1
Synonyms	MUC1/Y; MUC1; MUC-1; Mucin-1; Mucin1; CA 15-3; Episialin; H23AG; KL-6; PEMT; PUM; PEM; EMA; CD227;;CA15-3; KL6
Accession	P15941-7
Species	Human
Biotinylated	no
Amino Acid Range	Ser24-Gly158
Molecular Weight	The protein has a predicted MW of 41.38 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human Mucin-1 Isoform Y on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Mucin-1 Isoform Y is greater than 90% as determined by SEC-HPLC.